Big Brain Holdings Invests in Seed, Pre-Seed and Early Stage Startups

Big Brain Holdings

Ahmed Al-Balaghi

Daedalus

Auros is an algorithmic trading and market making firm that delivers best-in-class liquidity for exchanges and token projects.

Auros Global

Frostlight

Haiku

United Kingdom

Wintermute is a truly value adding investor dedicated to supporting the innovation in the blockchain ecosystem.

Wintermute

United States of America

Investing in the crypto-powered Web3 and creator economy ecosystems

6MV (6th Man Ventures)

Robot Ventures primarily invests in projects and companies related to decentralized finance (DeFi), blockchain technology, cryptocurrencies, and the broader Web 3.0 ecosystem. They seek to identify promising early-stage projects that are building innovative solutions in these areas.

Robot Ventures

Chapter One Ventures

Hong Kong

Mirana Ventures is a leading global investment fund that provides long-term capital and strategic partnerships to visionary founders and fund managers in the Web3 space.

Mirana Ventures

Anatoly is the creator of Solana. He led development of operating systems at Qualcomm, distributed systems at Mesosphere, and compression at Dropbox. He holds 2 patents for high performance Operating Systems protocols, was a core kernel developer for BREW which powered every CDMA flip phone (100m+ devices), and led development of tech that madeProject Tango (VR/AR) possible on Qualcomm phones.

Anatoly Yakovenko

gainzy

doctor.sol

ceteris

Brady

nicovrg

BULK

Mechanism Capital is an investment firm that invests in the cryptocurrency industry with a focus on decentralized finance or DeFi.

Mechanism Capital

Animoca Brands is a global digital entertainment company that specializes in the development and publishing of mobile games, blockchain-based games, and non-fungible tokens (NFTs). They are known for creating and publishing a wide range of popular games, including licensed intellectual properties such as Formula 1, Doraemon, and MotoGP. Animoca Brands is also heavily involved in the blockchain gaming space, leveraging the benefits of blockchain technology and NFTs to create unique gaming experiences.

Animoca Brands

Slovakia

Zee Prime Capital is a VC firm based in Bratislava, Slovakia. Investing in programmable assets and early-stage founders globally.

Zee Prime Capital

Managed by the family office of Arthur Hayes (co-founder, BitMEX), Maelstrom is building a long-term portfolio of infrastructure companies that will serve as the foundation of the next wave of trustless decentralization.

Maelstrom

Foresight Ventures is an investment institution focusing on blockchain technology and crypto industry established in 2020, whose predecessor was an international private equity venture capital with more than ten years of investment experience.  We take solid research on market and technology as investment orientation when investing in both primary and secondary markets of equity and token, with nearly 80 million dollars asset under management.

Foresight Ventures

Panga Capital

BIO Protocol

Malta

YZi Labs is an investment firm formerly known as Binance Labs that invests in all stages of development in the fields of Web3, artificial intelligence (AI), and biotechnology.

YZi Labs (prev Binance Labs)

Germany

1kx is a venture capital firm that stands at the forefront of the blockchain and crypto space, focusing on investments in decentralized technologies and blockchain-based projects. Founded by Christopher Heymann and Lasse Clausen, 1kx has established itself as a key player in identifying and supporting early-stage companies that are pushing the boundaries of innovation in the crypto ecosystem.

Northpond Ventures

a16z crypto is a venture capital fund that invests in crypto and web3 startups

a16z crypto CSX

Solana Ventures' mission is to accelerate the growth of the Solana blockchain and adjacent ecosystems by providing capital to the most promising teams building in the crypto ecosystem.

Solana Ventures

Colosseum

Equilibrium.co

Reflect

Singapore

Crypto.com is a payment and cryptocurrency platform that empowers users to buy, sell, and pay with crypto.

Crypto.com

Selini is a global trading firm focused on systematic trading, liquidity provision, efficient execution, and venture investing—all within the digital assets space.

Selini Capital

HyperChain Capital

Republic is an investment platform providing access to startups, real estate, crypto, and video game investments.

Republic

Breyer Capital is a premier global venture capital and private equity investor focused on catalyzing high-impact entrepreneurs in the United States and China. Founded by Jim Breyer in 2006, Breyer Capital makes long-term, idea-driven strategic investments in its chosen core areas: social media, entertainment/media, digital health, andfinancial technologies.
Breyer Capital actively partners with a diverse set of companies including early-stage startups building breakthrough technologies, fast growing companies, and established worldwide leading corporations. Its team enjoys helping to frame strategic investments anchored by the passion of founders and owner/operator teams, the insights of its network of world-class investors, and a conviction that artificial intelligence, machine learning, and virtual reality will transform technology and investment opportunities globally.

Breyer Capital

Quantstamp

Web3.com Ventures

DNA Fund

Protein Capital

Hemi

TRGC invests in founders building category-defining companies at the forefront of digital assets, blockchain and blockchain-related companies.

TRGC

Impossible Finance is a multi-chain incubator, launchpad, and swap platform which offers a robust product-first ecosystem that supports top-tier blockchain projects to targeted user audiences.

Impossible Finance

China

SNZ Holding is a crypto fund founded by a group of engineers, blockchain evangelists and entrepreneurs passionate about disruptive blockchain technologies.

SNZ Holding

Alchemy provides a set of web3 development tools for easily building and scaling a decentralized application.

Alchemy

George Burke

Jihan Wu

Gate Ventures

Artichoke Capital is a technology venture capital firm supporting the next generation of founders advancing the development of Web3.

Artichoke Capital

Cypher Capital is a venture capital firm aimed at investing in early-stage blockchain projects.

Cypher Capital Group

The SALT Fund

Capital6 Eagle

BTC Inc

Sunflower Fund

Framework Ventures is a cutting-edge venture capital firm deeply immersed in the world of decentralized finance (DeFi) and blockchain technology. Founded by Michael Anderson and Vance Spencer, Framework Ventures stands out as a key player in the rapidly evolving landscape of digital assets and blockchain-based financial innovations.

Framework Ventures

The CMT Group has acted as a valued collaborator to numerous exchanges, clearing firms, and trading and investment teams, generating edge by pairing market insight with early adoption and innovation of nascent technologies.

CMT Digital

Dragonfly Capital Partners, commonly referred to as Dragonfly Capital, is a venture capital firm that focuses on investments in the blockchain and cryptocurrency space. Dragonfly Capital is known for its active involvement in the blockchain and crypto industry and its commitment to supporting innovative projects and companies.

Dragonfly Capital

Arbitrum Foundation

Bullish is a digital asset exchange that provides deep liquidity.

Bullish

Flowdesk

Hermeneutic Investments

USD.AI

Electric Capital is a venture capital firm that focuses on investments in blockchain and cryptocurrency-related projects and companies. Founded by Avichal Garg and Curtis Spencer, Electric Capital is known for its active involvement in the cryptocurrency space and its support for innovative blockchain technologies.

Electric Capital

Pantera Capital is a blockchain and cryptocurrency-focused investment firm and hedge fund. It was founded in 2013 by Dan Morehead, who is a former Wall Street executive and chief financial officer (CFO) at Tiger Management. Pantera Capital is known for being one of the earliest institutional investors in the cryptocurrency space and has been actively involved in supporting the growth and development of blockchain technology and digital assets.

Pantera Capital

Arrington Capital is a thesis-focused digital asset and Web3 investing firm. Since 2017, Arrington Capital has invested in over 200 early-stage companies in the crypto ecosystem. Arrington Capital's crypto-native team of seasoned entrepreneurs, founders, and executives is committed to doubling down on efforts to ensure our partners' success.

Arrington Capital

ParaFi Capital is an alternative investment firm focused on blockchain and decentralized finance markets.

ParaFi Capital

Galaxy is a digital asset and blockchain leader helping institutions, startups, and qualified individuals shape a changing economy.

Galaxy

GSR Ventures is a venture capital firm focused on early-stage technology companies developing AI-enabled enterprise software, consumer platforms, and healthcare technology.

GSR Ventures

Paper Ventures is a first-in, innovative investment firm, focusing on the ever-changing landscape of emerging technologies.

Paper Ventures

Netherlands

Venture Capital Fund in Blockchain & Distributed Ledger Technology (DLT)

Maven 11 Capital

Borderless Capital is a Blockchain VC firm and a modern financial institution investing capital and co-building financial products with our portfolio companies that accelerates access, bootstraps adoption, and creates value globally through the Algorand Borderless Economy.

Borderless Capital

FalconX

Mexico

Lvna Capital is an investment fund specialized in blockchain-based digital assets.

Lvna Capital

dao5

Protagonist is a crypto fund and incubation lab supporting foundational protocols in emerging blockchain ecosystems.

Protagonist

Sui Foundation promotes and implements the Sui network by supporting the community of its developers and creators.

Sui Foundation

Comma3 Ventures

Karatage

ATW Partners

Mill City Ventures III

Upexi

Delphi Ventures was founded over 25 years ago as one of the first venture capital firms to focus on investing in life sciences companies.

Delphi Ventures

White Star Capital is an international venture and early growth-stage investment platform in technology.

White Star Capital

GSR, founded in 2013, is a global leader in digital asset trading and market making.
GSR is a crypto market maker and ecosystem partner

GSR Markets (GSR)

Delta Blockchain Fund has actively partnered with entrepreneurs since the beginning of Delta's lifecycle in September 2021. We’re proud to have backed multiple companies and to be their cheerleader throughout their journey.

Delta Blockchain Fund

Morgan Creek Capital Management, LLC is an SEC-registered investment adviser

Morgan Creek Digital

Anagram Crypto

Austin Federa

Bartosz Lipiński

Elune Capital

Larry Wu

Allan Marshall

Joey Krug

Blockchain Founders Fund (BFF) is a Singapore based early-stage Venture Capital Fund which invests in top-tier Blockchain startups globally.

Blockchain Founders Fund

Blizzard Fund (Avalanche Ecosystem)

London Real Ventures

GS Futures

Trive

Eckhardt Capital

Andrew Durgee

Cosmos Hub

Sphinx Protocol

FarmerJoe

Robert Chen

macbrennan

Gaius

Ashwath

alexbond

mhonkasalo

Fermi Labs

Solana Foundation is to build, support, and grow the Solana network and its community while driving mass adoption for blockchain.

Solana Foundation

Balaji S. Srinivasan is the CTO of Coinbase and cofounder of Counsyl, Earn, Teleport, and Coin Center. He was previously CEO at Earn.com, which was recently sold to Coinbase. Prior to taking the CEO role at Earn.com, Dr. Srinivasan was a General Partner at Andreessen Horowitz. Prior to joining a16z, he was the cofounder and CTO of FoundersFund-backed Counsyl, where he won the Wall Street Journal Innovation Award for Medicine and was named to the MIT TR35. Dr. Srinivasan holds a BS, MS, and PhD in Electrical Engineering and an MS in Chemical Engineering from Stanford University. He also teaches the occasional class at Stanford, including an online MOOC in 2013 which reached 250,000+ students worldwide.

Balaji Srinivasan

Coinbase Ventures is the venture capital arm of Coinbase, one of the largest and most well-known cryptocurrency exchanges in the world. Coinbase Ventures is focused on investing in early-stage companies and projects in the blockchain and cryptocurrency space. It provides funding, resources, and support to startups and entrepreneurs working on innovative blockchain and crypto-related technologies and applications.

Coinbase Ventures

Santiago Roel Santos is the Partner at ParaFi Capital

Santiago Roel Santos

MonkeVentures

We offer investors intelligently designed investment strategies that take advantage of targeted market opportunities.

VanEck

Kash Dhanda

Akshay BD

Matt Sorg

Pharsalus Capital

Arnold Lee

Latif Peracha

Raj Gokal

Philippines

Stepan Simkin

Andrew Kang is a cryptocurrency entrepreneur and investor. He is the Co-Founder of Mechanism Capital which invests in cryptocurrency through prop trading, mining, ventures, and secondary markets. Kang previously worked in portfolio management and venture capital at Digital Capital Management.

Andrew Kang

Nic Carter

Endeavor Catalyst

The Spartan Group primarily focuses on investments in digital assets, cryptocurrencies, and blockchain-related projects. They actively manage a portfolio of various cryptocurrencies, including Bitcoin and Ethereum, as well as other tokens and blockchain assets.

The Spartan Group

CMS Holdings may also invest in early-stage blockchain and cryptocurrency projects through private investments and strategic partnerships. They provide capital and support to innovative startups in the crypto space.

CMS Holdings

NGC Ventures is one of the largest institutional investors of blockchain technologies, and has been a key contributor to a number of leading projects.

NGC Ventures

LongHash Ventures is a global blockchain accelerator and VC fund.

			La etapa	Inversores
Haiku	$1.00 M	~$10.00 M	Pre-seed	+2		DEX	Dec 4, 2025
BULK	$8.00 M	~$80.00 M	Seed Round	+9	--	DEX	Sep 24, 2025
BIO BIO Protocol	$6.90 M	~$69.00 M	Seed Round	+5		DeSci	Sep 17, 2025
Reflect	$3.75 M	~$37.50 M	Seed Round	+2		DeFi	Sep 2, 2025
HEMI Hemi	$15.00 M	~$150.00 M	Funding Round	+8		Modular Blockchain	Aug 26, 2025
USD.AI	$13.40 M	~$134.00 M	Series A	+5		DeFi	Aug 14, 2025
Mill City Ventures III	$450.00 M	~$4.50 B	Post-IPO	+16		Finance	Jul 31, 2025
Upexi	$150.00 M	~$1.50 B	Funding Round		--	Finance	Jul 10, 2025
Sphinx Protocol	$2.00 M	~$20.00 M	Pre-seed	+6		Blockchain	Jun 23, 2025
Fermi Labs	--	--	Pre-seed	+7		DeFi	May 21, 2025
ZAR	$7.00 M	~$70.00 M	Funding Round	+22		Finance	Apr 30, 2025
Upexi	$100.00 M	~$1.00 B	Post-IPO	+12	--	Finance	Apr 21, 2025
Optimum	$11.00 M	~$110.00 M	Seed Round	+12		Infrastructure	Apr 15, 2025
Ambient	$7.20 M	~$72.00 M	Seed Round	+12		Blockchain	Mar 31, 2025
Crossmint	$23.60 M	~$236.00 M	Series A	+4		Blockchain Service	Mar 18, 2025
Vest Exchange	$5.00 M	~$50.00 M	Funding Round	+13		DEX	Mar 12, 2025
M10	$3.00 M	~$30.00 M	Seed Round	+4		Gaming	Mar 12, 2025
Fortytwo	$2.30 M	~$23.00 M	Pre-seed	+6		Infrastructure	Mar 6, 2025
MVRK Mavryk Network	$5.20 M	~$52.00 M	Funding Round	+3		DeFi	Feb 25, 2025
Acre	$4.00 M	$90.00 M	Strategic Round			DeFi	Feb 20, 2025

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